Nathan S. Bryan, PhD is an academic and entrepreneur who has focused his career on the study of nitric oxide for nearly 25 years. He joins the podcast to contribute to the Evolution of Medicine’s current focus on cardiovascular and endothelial health.

Nitric oxide production is foundational to overall health. Unfortunately, many contemporary environmental and lifestyle factors reduce or prevent nitric oxide production in the body. Suboptimal nitric oxide production is a factor in insulin resistance, cardiovascular issues, erectile dysfunction, long COVID and other post-viral syndromes, chronic fatigue, cognitive disorders, and more.

Tune into this episode to learn about the many lifestyle and environmental factors that can impede or support the production of this important molecule. Some may even surprise you!

Listen to the episode to learn more about:

  • Nitric oxide’s role in cardiovascular, immune and nervous system function
  • The gold standards for measuring functional nitric oxide production
  • James’ and Dr. Bryan’s views on the public health response during the COVID era
  • Using nitric oxide to heal inflammation caused by excess spike protein
  • The risks of using some commercially available products that claim to boost nitric oxide

Also, check out Dr. Bryan’s educational website, which includes a blog, videos and more:

Nitric Oxide: The Key to Heart Health | Ep. 299

Dr. Nathan Bryan: So, everything we do now is trying to provide the right information, the right science, educate, inform consumers, as well as healthcare practitioners and physicians, so that they now hopefully appreciate the importance of nitric oxide and start asking the right questions to your patients, and considering nitric oxide as not only a cause for many diseases, but also the solution.

James Maskell: Welcome to the Evolution of Medicine podcast, the place health professionals come to hear from innovators and agitators leading the charge. We cover the latest clinical breakthroughs in health technology, as well as practical tools to help you transform your practice and the health of your community. This podcast is brought to you by the Lifestyle Matrix Resource Center, who provide a range of options to help you deliver successful, effective, functional, and integrative medicine. To find out more and to get started, go to That’s

Hello and welcome to the podcast. This week, we are talking about all things nitric oxide. This is critical to understand whether you are in the business of keeping people healthy, whether you are understanding heart health specifically and you’re working with patients who are on the journey towards cardiovascular dysfunction.

But also, if you listen to the end of the podcast, we got into really understanding heart dysfunction in the age of COVID, in the age of the COVID vaccines, and the critical role of nitric oxide in understanding vascular inflammation and its tie to sudden heart attacks. This was a really, really interesting half an hour.

Dr. Nathan Bryan is a ex-professor. He is a physiologist and biochemist, and I think you’ll get a lot from the time here. He’s certainly a nitric oxide leader, and he’s been part of the field for more than 25 years. It was a really fascinating half an hour. Make sure that you listen right to the end. Thanks so much for tuning in and enjoy.

So, a warm welcome to the podcast, Dr. Nathan Bryan, thank you for being on here.

Dr. Nathan Bryan: James, thank you so much for having me. It’s a great pleasure.

James Maskell: So, yeah, here at the Evolution of Medicine, for the first quarter, we’re really focused on heart health and all aspects of healthy heart function, and the conversation of nitric oxide has come up many times in our planning and what practitioners were looking for and wanting to find out more about. So, why don’t we just jump into it here today? So, why don’t you take us back to the beginning of how you got involved in nitrous oxide research?

Dr. Nathan Bryan: Well, thanks, James. I think there’s nothing more important topic, as it relates to heart and cardiovascular health, than nitric oxide. I’ve been in the nitric oxide field for almost 25 years. I first got into this field of research back in the late ’90s, early 2000s.

A Nobel Prize had just been awarded for the discovery of nitric oxide in 1998, so the scientific community knew it was an important molecule, but there were still so many unanswered questions, even back then, like how the body produces it, what goes wrong and people that can’t make it, and then how do you fix or overcome nitric oxide deficiency. Now, fast-forward 25 years, we’ve basically solved that riddle, and we have all the answers we need in order to develop safe and effective nitric oxide-based technologies, therapeutics, nutritional products.

But I think it’s important that your listeners understand what nitric oxide is. It’s a signaling molecule. It’s produced in the lining of the blood vessels. It’s produced in other cell types. But it’s really the most cardioprotective molecule produced in the human body. It controls and regulates blood pressure, blood flow, oxygen delivery. It’s a neurotransmitter in the central nervous system, and it’s how our immune system kills off viruses and bacteria or any invading pathogen, for that matter.

James Maskell: Interesting. Yeah. I was semi-aware of that. You mentioned now everyone kind of knows… I guess there’s an understanding of some of the mechanisms. How is it produced?

Dr. Nathan Bryan: Well, back in 1992, nitric oxide was called the miracle molecule, and miracles allude to the fact that it’s unexplained. In 1992, we couldn’t explain a lot of the biological actions of nitric oxide. Today, we have a clear understanding of mechanistically, how it works, how the body produces it, and then what signaling aspects or what biological effects result from nitric oxide.

But the fundamental question is the question you just asked. How does the human body produce nitric oxide? And now we know there are two primary methods of production. One is through an enzyme called nitric oxide synthase. That enzyme’s found in the cells that line the blood vessels, are found in neurons, other cell types throughout the body. And that enzyme converts L-arginine, which is a semi-essential amino acid into nitric oxide, and you get citrulline as a byproduct. And that’s really an energetically and kinetically unfavorable reaction, the five electron multi-step oxidation reaction.

And what we’ve found is that that pathway is what becomes compromised with time. The older we get, the less nitric oxide we make, and we call that endothelial dysfunction. And so, you can overcome endothelial dysfunction and compensate for a loss of nitric oxide through another pathway which utilizes diet, and specifically, inorganic nitrate found primarily in green leafy vegetables that, when consumed, if you have the right oral nitrate reducing bacteria, the bacteria in the mouth convert or metabolize that nitrate into nitrite and nitric oxide, and then when you swallow your saliva, you get a burst of nitric oxide gas.
Now, this pathway has been shown to lower blood pressure, improve exercise performance, kill pathogens, like H. pylori, the ulcer-causing bacteria, E. coli, Salmonella, most infective and ulcer-causing bacteria. So, a critical, fundamental physiological process that generates nitric oxide. Yes.

James Maskell: So, that first pathway, has that been deemed to be irreversible and just part of natural senescence? Or is there effort to understand that as well?

Dr. Nathan Bryan: No, most of the time, it’s reversible, but I will say that there’s a time in every disease process where it becomes irreversible. But if we catch this early on, and what we call endothelial dysfunction or the inability of the endothelium to produce nitric oxide, we and others have been shown to completely reverse that. We understand now the enzymology and the biochemistry of that enzyme, that we know what leads to the dysfunction, we know what causes uncoupling, and now we can actually recouple that enzyme and restore normal endothelial function and nitric oxide production.

James Maskell: Interesting. So, can you describe the role of nitric oxide in the heart, in the blood vessel, I guess?

Dr. Nathan Bryan: In terms of heart health, we look at the electrical potential or the electrical conductance of the heart, which maintains the contractility and the beating of the heart, but we also have to understand the plumbing, the blood vessels of the heart. And cardiovascular disease remains the number one killer of men and women worldwide today. It’s usually a buildup of a plaque or loss of vasoactivity of the coronary arteries.

Nitric oxide, when it’s produced, it’s a gas, so part of it diffuses into the smooth muscle of the blood vessels where it activates an enzyme called guanylate cyclase, and then that enzyme produces a second messenger, which causes dilation, which is smooth muscle relaxation, which results in dilation of the artery. When you dilate the blood vessels, obviously, you’re getting more blood flow, more oxygen delivery to them.

When you lose the ability to make nitric oxide, you lose the ability to dilate the blood vessels, and this is the main mechanism for improving oxygen extraction from the coronary arteries into the heart because typically, under normal basal conditions, you’re extracting maximal oxygen with normal coronary flow. So, the only way to improve oxygen delivery to meet the increased metabolic demands on the heart, for instance, when we begin to exercise, the only way to do that is through vasodilation, and the main vasodilator is nitric oxide.

If you can’t make nitric oxide, you become exercise intolerant and develop exercise or exertional angina, the inflammation in the artery increases, and you get stiff arteries that are unable to dilate, and that causes ischemic heart disease. The plaque becomes unstable, the plaque ruptures, and that’s heart attack. Everything we know about heart attack, strokes, cardiovascular disease, revolves around the production of nitric oxide, so the functional loss of nitric oxide precedes these structural changes by many years, sometimes decades.

James Maskell: Okay, interesting. So, I guess, how do you determine that that nitric oxide deficiency that’s happening early on… How would a practitioner in our community identify that in a patient? And what are some of the conditions that you would see in that journey to dysfunction?

Dr. Nathan Bryan: Well, many cardiologists for many decades now have been using an indirect measure of nitric oxide production, and it’s the exercise stress test. So, when a cardiologist or your primary care doc puts you on a treadmill and increases the workload, you can detect changes in electrical activity, and that changes in electrical activity is due to ischemia or reduced blood flow in the heart, so if you can’t dilate the coronary arteries because you can’t make nitric oxide, then you develop this ischemia, which then leads to changes in electrical activity of the heart, and you can see this in an EKG. So, an exercise stress test is really the way to measure functional nitric oxide production.

There’s now some FDA cleared medical devices that look at what’s called flow-mediated dilatation, which is a measure of endothelial function. There’s some pulse-wave analysis devices that can measure the stiffness of the arteries and looking at the reflective wave from each beat of the heart. Years ago, I developed a salivary test strip that would give physicians the first point of care, non-invasive diagnostic for nitric oxide.

Those are useful tools to have in your toolbox. The salivary test is a good tool to have in your toolbox, but there’s some false positives to that test that physicians and healthcare practitioners need to be aware of. But really, still, the gold standard is exercise stress test and flow-mediated dilation.

James Maskell: Okay. And you would say that most of the diagnosis of this would be done in a cardiologist’s office? Is this important for a sort of more primary care-ish providers to understand?

Dr. Nathan Bryan: Well, no. We think that really the frontline are primary care docs. If you’re referred to a cardiologist, then obviously, you already have symptoms that are of concern and onset of disease. The role of the primary care doc is to keep you well and diagnose symptoms early on that lead to the onset and progression of disease. Our efforts have always been to arm the primary care doc on understanding the role of nitric oxide, and I think we’re making some headway there. But we really rely on symptoms, and it’s the symptomology that tells us if a patient is deficient in nitric oxide.

So, for instance, if you have an unsafe elevation in blood pressure, that tells us that your body’s not making nitric oxide. If you have erectile dysfunction, in both men and women, that tells us that the blood vessels of the sex organs can’t make nitric oxide to dilate the blood vessels to get engorgement. If you have insulin resistance and type 2 diabetes, nitric oxide is critically important in insulin signaling. Insulin-resistant type 2 diabetes is a symptom of nitric oxide deficiency.

James Maskell: Interesting.

Dr. Nathan Bryan: If you get shortness of breath by climbing up a flight of steps or taking a walk, then your body’s not making enough nitric oxide. You develop mild cognitive disorders and vascular dementia, or even Alzheimer’s. That’s a symptom of nitric oxide deficiency, and it tells us that your brain isn’t getting enough blood flow for these cells to do their job.

James Maskell: That’s really interesting. All right, then. So, let’s talk about improving it. You mentioned earlier the dark leafy greens, but what would you recommend for people to think about how to increase nitric oxide, I guess, first with lifestyle factors?

Dr. Nathan Bryan: Well, that’s always our first approach: understand what are you doing in your diet and lifestyle that may be inhibiting nitric oxide production or could actually stimulate it. That’s probably the most common question I get is, “How do I improve my nitric oxide production?” I tell people, “You have to do two things: you have to stop doing what inhibits nitric oxide production, and then you got to start doing what’s clinically proven promote it.”
We’ll take those step-by-step because these are very important. Now we know what’s inhibiting nitric oxide production. Number one, we’re not getting enough nitrate from the diet. The Standard American Diet is really depleted of any nitrate, just like most other nutrients, like iodine and magnesium and chromium. So, our diet is deficient in nitrate. Number two…

James Maskell: Even with widespread use of like nitrogen fertilizer, that doesn’t add to it?

Dr. Nathan Bryan: Well, it certainly helps, but there’s a big phase and a craze about organically grown vegetables, and to get an organic label, you’re not allowed to add nitrogen-based fertilizers to the soil.

James Maskell: Okay.

Dr. Nathan Bryan: So, as a result, these veg… The soil is deficient in nitrogen. The plants that are grown in these soils are deficient in nitrate, nitrogen. When we consume these, we’re not getting enough nitrogen in the form of nitrate to generate nitric oxide. So, that’s number one.

Number two is, we’re dependent upon the oral bacteria. There’s 200 million Americans that wake up every morning and use mouthwash, and when you use mouthwash, you’re killing the good bacteria, you’re killing the bad bacteria, you’re disrupting the diversity of the oral microbiome, and you become nitric oxide deficient. We and others have published on this. If you use mouthwash, your blood pressure goes up, you lose the cardioprotective benefits of exercise.

So, if you’re using mouthwash, you have to stop. We know that we should not take an antibiotic every day for the rest of our life because of the systemic effects of disrupting the gut microbiome, so why would you use an oral antiseptic every day to disrupt the oral microbiome when there’s clear evidence now this causes an increase in blood pressure, it causes sexual dysfunction, you lose the benefits of exercise. If you’re using mouthwash, you have to stop. That’s number one.

Number two, you have to get rid of fluoride. Fluoride’s an antiseptic. If you’re using fluoride toothpaste, get a non-fluorinated toothpaste. There’s fluoride in most municipal water systems, so you have to get a water purification system to get rid of fluoride. As I mentioned, it’s an antiseptic. It kills bacteria. It’s a neurotoxin, and it kills your thyroid function. Fluoride is a really, really nasty molecule. It’s toxic, and you should try to eliminate it from exposure.

And then thirdly, you have to get off antacids. Proton pump inhibitors and these antacids shut down nitric oxide production from both pathways, and now, there’s clear evidence that people who have been on PPIs, things like Prevacid, Priolsec, Omeprazol for three to five years have about a 35 to 40% higher incidence of heart attack and stroke. These are very dangerous drugs. They were never approved for chronic use, but yet, we’ve got patients that have been on these drugs for decades, and yet the consequences are deadly. 40% increase in heart attack and stroke.

If you stop doing those three things, stop using mouthwash, stop using fluoride, get rid of antacids, now your body can actually do what it’s designed to do in terms of generating oxide. So, that’s first.

Now, what can you do to promote it? Throw in some more green leafy vegetables, as we discussed. Moderate physical exercise, as little as 20 to 30 minutes a day. Sunlight. I like infrared saunas, infrared light. There’s certain wavelengths of light that’ll stimulate nitric oxide production or release nitric oxide from preformed stores, what we call photolabile stores.

And then when all else fails, then we have product technology that does it for you. But it’s really very simple. The complex of nitric oxide science is very complex, but the solution to nitric oxide deficiency is really simple.

James Maskell: Yeah, it’s really interesting. Obviously, in the world of functional medicine, there are some conditions where it’s really possible quite easily and elegantly to reverse a chronic condition. And then there’s some where the degeneration feedback loops kick in, and it’s harder to take it back. From your experience, is someone in their middle age who really starts to do the things that you’ve mentioned and they’re measuring it effectively… Is this something that can rebound pretty well?

Dr. Nathan Bryan: Absolutely. We’ve seen this over the past 10 or 12 years. One of the most gratifying things for me is getting the hundreds of texts, phone calls, and emails of people we’ve changed their life that have been living with a poorly managed chronic disease for many, many years, and just by employing these simple strategies, we’ve changed their life.

But I just want to make it very clear that nitric oxide is not an end all, be all, cure all. We think it’s foundational for human health, but it’s not going to replace a missing nutrient, like iodine or magnesium. I’ve learned over the past 25 years that people get sick for two reasons and two reasons only: the body’s missing something that it needs, or it’s exposed to something that it doesn’t need.

If you can’t make testosterone or estrogen or vitamin D, nitric oxide is not going to fix that. We have to fix the missing components, and that’s the beauty of functional medicine. You look at the whole patient in terms of personalized medicine, figure out what’s wrong in that. Are they missing nutrients? Are they exposed to a toxin? And if you remove them from the source of exposure of toxins, then replete missing nutrients, the body heals itself.

Now, without nitric oxide, it can’t properly heal, because you’re not going to get the blood flow, you’re not going to get oxygen delivered, you’re not going to get the nutrients delivered to individual cells of their body so they can do their job. But foundationally, nitric oxide, your body cannot and will not heal without nitric oxide.

We think, and we’ve seen this and experienced this over the past 20 years, that it’s really been the missing piece in getting patients better, whether it’s allopathic medicine or whether it’s functional, integrative medicine. Nitric oxide is certainly the key to making patients better.

James Maskell: So, on the supplement side, what are things that you’ve seen? Are there nutrients that can support lifestyle intervention and increase nitric oxide production?

Dr. Nathan Bryan: Yeah, there is, James, but, you know, consumers are confused, and there’s a lot of companies out there that are putting a lot of misinformation and disinformation out in the public. So, you know, there have been a number of nitric oxide products on the market, hundreds perhaps, since the late ’90s.

There’s two classes of nitric oxide products. There’s what we call the arginine-citrulline-based products that really have no clinical benefit. These are semi-essential amino acids. The body makes enough through the urea cycle to saturate the binding of the nitric oxide synthase enzyme, so if you’re using arginine or citrulline based products, save your money, they’re useless. And in fact, there’s a couple of clinical studies showing that these products can actually do more harm than good.

In a study in 2006 in the General American Medical Association, arginine actually killed more people in post-infarct patients in a clinical trial than the placebo. That trial was actually stopped. Arginine should not be, in fact, it’s contraindicated, in patients with a previous heart attack. Similar results were obtained giving arginine to patients with peripheral artery disease. They actually got worse. Intermittent claudication basically got worse. Quality of life got worse.
So, these products… The enzymology and biochemistry, if anybody knows anything about nitric oxide, you know that arginine and citrulline products do not work and cannot work biochemically. So, you’ve lost the ability… The enzyme that converts arginine to nitric oxide becomes dysfunctional, so you’re never deficient in arginine. And then citrulline is even more common. Citrulline is a byproduct of nitric oxide production. Really, there’s no need for that, either. So, those products, that’s simple. If you got a product that contains arginine or citrulline, you probably shouldn’t take it.

The others are beet products. There’s been a number of beetroot products that have hit the market since probably 2012. I’ve tested these. 97-98% of these products don’t do anything. They don’t contain any nitrate, nitride, no nitric oxide activity whatsoever. There’s people out there selling beet chews or heart chews or whatever this is. Again, nitric oxide’s a gas. It’s not stable and liquid. You can’t put it in chews, any of these hydrated gels.

What we do is completely different. We create an orally disintegrating tablet that, when you place this lozenge in your mouth, that actually generates nitric oxide gas. Our philosophy is, if your body can’t make nitric oxide, we do it for you, but we also understand how that enzyme works, and so we recouple that enzyme and actually improve the body’s ability to make nitric oxide on its own.

James Maskell: Interesting. All right. So, we’ll follow up with more on that, and we’ll have some details in the show notes about that. So, what are you working on now? Where’s your research focused?

Dr. Nathan Bryan: Well, now, since I’m kind of retired from full-time academia, my focus is bringing innovative nitric oxide technologies to every market segment around the globe. I’m most excited about our drug discovery program. We’ve got a drug company called Nitric Oxide Innovations. We just finished a phase three clinical trial with our nitric oxide drug in high-risk COVID patients.

We’ve got some drug studies going on now for ischemic heart disease, ischemic non-obstructive coronary artery disease, Alzheimer’s. And we’ve developed a topical nitric oxide drug for diabetic and pressure ulcers that I think and I believe will transform the treatment of diabetic ulcers and chronic wounds. There have been no innovations in wound care for the past 60 years. Nitric oxide kills the infection in wounds. It improves blood flow and hyperemia to where you get tissue granulation, and we’re taking three- to four-year-old, non-healing ulcers and healing them within a matter of weeks or months.

James Maskell: Wow.

Dr. Nathan Bryan: The COVID study really revealed a lot about the important role of nitric oxide in COVID infection and the progression of COVID disease. We recognized early on in COVID, in March of 2020, that the people that were getting sick and dying from COVID were the people that couldn’t make nitric oxide. These were the elderly, African Americans with previous heart attack, diabetes, kidney disease, liver disease.

So, our whole thought process was, if we can restore nitric oxide production in these high-risk patients early on, within 72 hours of exposure, onset of symptoms, could we prevent the progression of disease, keep these patients out of the hospital, keep them off a ventilator? And if you can do that, you can keep them alive. And what we found was we could improve blood oxygen saturation by about 15 to 20% in the active group. The symptomology improved, so people didn’t get as sick, and if they did get sick, the symptoms were much milder.

And then looking at the vascular inflammation from long COVID, the systemic disease that persists long after the active infection, all that can be explained by the inflammation caused by the spiked protein, by the increase in adhesion molecules in the endothelium. Nitric oxide suppresses the expression of the adhesion molecules. It prevents platelets from clotting so you don’t get the micro clots, you don’t get the vascular inflammation, and it basically ameliorates all symptoms of long COVID.

Nitric oxide is critical in COVID, or really any respiratory infection. Whether it’s COVID or the next infectious pathogen, nitric oxide’s still going to be at the front lines for preventing the onset and expression of respiratory illness or any viral infection.

James Maskell: Yeah, that’s really interesting. Obviously, COVID had a specific effect there. I think, now, here we are in 2023, and we have a lot of patients coming into functional medicine doctors who are unexpectedly now dealing with, I would say, heart complications as a result of either COVID or excess spike protein in the body from excess vaccinations and boosters.

Dr. Nathan Bryan: That’s right.

James Maskell: What role for nitric oxide intervention? Could it be used preventatively to improve heart function as a preventive measure for future unknown effects with too much spike protein?

Dr. Nathan Bryan: Sure. This is the great experiment in the history of mankind and medicine was giving an mRNA vaccine that overexpresses the spike protein, which we know the spike protein is toxic, causes the vascular inflammation, causes endocarditis, myocarditis, is causing a lot of health problems. But mechanistically, we know that the etiology of the toxicity of the spike protein all revolves around the vascular endothelium. It increases expression of adhesion molecules. The spike protein binds to the ACE receptor, and then that’s how it enters the cell.

Nitric oxide is what downregulates the ACE receptor. Nitric oxide prevents the coronavirus from replicating. Whether you have long COVID from active infection or you get these health problems now from the overexpression and continual production of the spike protein from the mRNA shots, the only way to combat this is to reduce the vascular inflammation. The only way we know how to do this is through safe and effective nitric oxide-based therapies.

The other problem are the micro-clots in the increase in heart attacks and strokes from the clot formation and emboli. Nitric oxide prevents the platelets from clotting, prevents the aggregation of platelets and monocytes and neutrophils sticking to the lining of the blood vessel. So, I think there’s still a lot of unknowns, but what we do know about nitric oxide, that it should be a frontline therapy or frontline defense from the toxic effects of the spike protein.

James Maskell: Yeah. More recently there’s been some pretty interesting studies about the effect of exercise on COVID outcomes. Is this probably one of the mechanisms that affected that? I’d imagine, given how effective exercise is in improving nitric oxide, I think I could certainly experience that myself with some of the symptoms that you mentioned and getting back into strenuous exercise, but those numbers were really fantastic, and it makes me think that that was part of the mechanism.

If it’s so important to have nitric oxide function for heart health, and nitric oxide production is so affected by exercise, it kind of makes sense that that would be some of the mechanism of why exercise was so effective at reducing the symptoms of COVID, long COVID and all that.

Dr. Nathan Bryan: Absolutely. There’s no doubt that we have to get to the root cause and the etiology of the symptoms of COVID and the spike protein, and it all revolves around vascular inflammation. And we know that exercise is anti-inflammatory, it induces the state of hormesis, so you get these brief episodic insults of ischemia or hypoxia that then lead to an upregulation of nitric oxide production, improved oxygen delivery and anti-inflammatory effects of exercise.

All of that makes sense. And I think, again, you have to stop doing the things that disrupt nitric oxide production, start doing the things that promote it, and I think that’s going to have the biggest effect on public health.

James Maskell: Well, look, I just want to finish this podcast by honoring something. This year for us, the word of the year is the year of connection, and a lot of the connections that you made here in the last five minutes, and some of the things that you’ve asserted, makes total sense to me, and I’m following you every step of the way, and I think many practitioners will be. However, most medicine isn’t, really. The understanding of the toxicity of a spike protein as an example was contentious in 2021, still contentious in 2022. I don’t know if it’s going to become less contentious in 2023.

I just want to honor you for making those connections because ultimately, I feel like there’s an amazing opportunity for our community to become the trusted resource and for this discipline of healthcare, health-focused care, whether you call that functional medicine, integrative medicine, whole-person care, lifestyle medicine. There’s an opportunity here now to claim the trust of the public because this is our sort of time to shine, and I hope that everyone who’s listening can realize how heavy what you shared is, but how clear the path forward is for our community.

I think in a lot of cases, we maybe missed a trick in this last few years by not being as clear with our own principles and understanding as we could have been.

Dr. Nathan Bryan: Yeah. Well, there’s a quote I like. It’s, “The greatest enemy of knowledge is not ignorance; it’s the illusion of knowledge.” Over the past three years, we’ve been duped by the so-called experts, and I think the American people have become too trusting. I encourage people to ask questions, get the information. I’m trained as a biochemist and physiologist, so I like to think that I understand how the human body works and how do we give the body what it needs to heal itself.

We have to ask questions. That’s how science evolves. Question, and to continue the question to get the right answers. So, I agree with you. We have to be diligent. It’s clear that the way we do medicine in the Western world isn’t working. To continue to do the same thing over and over again is insanity. We have to look differently, we have to think differently, and we have to act differently.

The basic science only works if we can get it in the hands of the physicians and the healthcare practitioners to actually put it in practice. That’s why I think what you do is so important, James, and I can’t thank you enough for the opportunity to come on and help educate your listeners.

James Maskell: Awesome. So, for practitioners who are listening to this who want to find out more about your work or want to get engaged with some of the technology that you’re working with, what’s the best way to find you?

Dr. Nathan Bryan: I’m certainly searchable online with any search engine, but I send people to my educational website. It’s I do a monthly blog. I’ve got a YouTube channel. You can find me on most social media platforms and Twitter. I’m Dr. Nitric on Instagram. I’m Dr. Nathan S. Brian. I’m on LinkedIn. Everything we do now is trying to provide the right information, the right science, educate, inform consumers, as well as healthcare practitioners and physicians, so that they now hopefully appreciate the importance of nitric oxide and start asking the right questions to your patients, and considering nitric oxide as not only a cause for many diseases, but also the solution.

James Maskell: Well, thanks so much for being part of it. This has been really educational for me, and I know for so many practitioners, and really appreciate your work, and thanks so much for being part of the Evolution of Medicine podcast.

Dr. Bryan: Thank you.

James Maskell: This has been the Evolution of Medicine podcast. I’m your host, James Maskell. We’ve been here with Dr. Nathan Bryan. We’ve got some great content coming up on this whole topic. All quarter, we’re talking about the heart, heart function, endothelial function, and we’ll look forward to the next step. Thanks so much for tuning in, and we’ll see you next time.

Thanks for listening to the evolution of medicine podcast. Please share this with colleagues who need to hear it. Thanks so much to our sponsors, the Lifestyle Matrix Resource Center. This podcast is really possible because of them. Please visit to find out more about their clinical tools like the group visit toolkit. That’s Thanks so much for listening and we’ll see you next time.


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